The market for erectile dysfunction (ED) solutions and medications is growing every year. However this does not necessarily mean that every possible option out there is going to be great and work 100%. As with any other medication, especially the prescription medications, you need to do your research carefully and make sure that the what you end up taking does not aggravate your ED symptoms.
The combinations and applications of various ED treatment options can be very roughly divided in oral, topical or injections. Usually if, for whatever reason, the oral prescription medications do not perform well, your medical professional may decide to offer you either topical preparations (TriMix gel for ED) or penile injections as an alternative for erectile dysfunction treatment.
Generally speaking, if you opt for the injections, the most commonly used medications are either a combination of phentolamine, papaverine and alprostadil (TriMix for ED), or a single chemical application of alprostadil. Here is a great trimix injection video describing the procedure.
Most of the studies report that the rate of success with TriMix for ED treatment hovers around 90% and the patients are, on average, quite responsive and agreeable with the difficulty of application and the achieved results. Before starting the ED injection treatment with TriMix, a thorough and careful preparation and training is recommended. As with any prescription medication, there are possible side effects that might include low blood pressure, bruising, pain, scarring or infection. Even though these side effects are pretty rare, you might experience some dizziness and occasional fainting, especially if done without appropriate training.
TriMix for ED as a combination therapy approach appeared in December of 1991 based on the scientific study done byÂ Bennett AH, Carpenter AJ and Barada JH. This study conducted inÂ Albany Medical Center, New York was called “An improved vasoactive drug combination for a pharmacological erection program” and reported an impressive success rate in study participants (92% in a study group of 116 patients).
As a general rule, TriMix injections for ED should not be used more than 3 times per week and the actual dosage should be tailored by your medical professional just for your own specific condition. By adjusting the exact dosage the targeted duration of the erection should not exceed 90 minutes. The requirement for the successful TriMix for ED treatment is that the vascular structure of the penis is healthy so that the application of the chemical ingredients is adequate.
If you have decided to find out even more detailed information about TriMix for ED treatment, here is a great article describing some suggestions about the dosage, side effects, injection techniques and general pros and cons of TriMix injections for ED (erectile dysfunction).
What is Trimix?
Trimix (also known as Trimix APP) is a combination of three active ingredients Atropine sulphate, Phentolamine mesylate and Papaverine hydrochlorid. It also contains benzalkonium chloride as a preservative. Trimix is not available âoff-the-shelfâ and must be specially prepared, or âcompoundedâ, by a compounding pharmacy.
What is Compounded Medication?
Compounded medication is medication prepared by a pharmacy for a patient from a doctorâs prescription. Compounding allows medications to be administered in tailored doses and forms to suit individual patient body requirements.
What Trimix is Used For?
Trimix is used for patients with erectile dysfunction (ED) who do not respond to, or are not suitable candidates for, other drug therapies. It is also used for those patients who respond painfully to single ED drug therapies such as prostaglandin E1 (alprostadil).
Before You Use Trimix for ED
Tell your prescribing doctor if you have any of the following conditions:
- Sickle cell anaemia, myeloma, leukaemia
- Hepatitis B or C
- Liver impairment
- Cardiovascular disease
- Penile fibrosis
- Penile implants
If you have any of the above conditions your prescriber will determine whether Trimix Injections For ED is a suitable treatment for you.
Your doctor will advise you of the correct dose for your ED condition and symptoms. Doses can start as low as 0.1mL and can increase by 0.1mL increments until the desired effect is achieved. Use no more than one injection in 24 hours and no more than three injections per week.
Trimix is administered by injections into the shaft of the penis using our pre-packaged Urology Kit. This contains 30 x 1mL syringes with 29 Gauge 12mm needles and 30 x alcohol swabs. The prescribing doctor or nurse may demonstrate the injections technique to you (see the trimix injection video we included above).
- Perform the self-injection procedure whilst sitting in an upright, slightly reclining or standing position.
- Inject only into the upper and outer part of the shaft (into the corpus cavernosum) at a 45 degree angle. See diagram below for an aerial view of injections areas. Do not inject into any visible veins, the top, or the underside of the penis.
Diagram 2 shows a cross-section of the penis. When compared to a clock face, if 12 oâclock is the top of the penis and six oâclock is the bottom, inject between the areas that correspond to one and three oâclock or nine and eleven oâclock.
- Preparing the injection:
- Wash hands and keep the penis clean.
- Have an alcohol swab, syringe, and the vial of injectable solution ready.
- The first time you use the vial you will have to remove the metal tab sealing on the top of the vial to expose the rubber seal below.
- Wipe the top of the vial with an alcohol swab.
- Remove the cap of the needle; fill the syringe with air by pulling back the plunger to the desired dosage.
- Insert the needle into the rubber top of the vial, inject the air, and then turn the vial upside down with the needle inside.
- Slowly pull back the syringe to the dosage required.
- Tap the side of the syringe so the air bubbles float to the top and inject out any air bubbles before use.
- Place the syringe on a level surface, ensuring the needle tip does not make contact with anything.
- Alternate the injection site each time; choose one side for this injection and use the other side next time, and so on. Within each area, the actual point of injection should also be changed each time.
- Open a second alcohol swab packet.
- Hold the head of your penis with your thumb and forefinger. Fully stretch your penis away from your body, straight ahead. If you are uncircumcised, the foreskin must be pulled back before you inject the solution.
- Clean the injection area with the second alcohol swab and let it dry.
- Keeping a firm grip on your penis, take the syringe in your free hand and gently rest the needle on your penis. With a steady, continuous motion, insert the entire length of the needle straight into the injection site.
- Push the plunger firmly with your thumb. This may require some pressure.
- Withdraw the needle from your penis. Apply pressure to the injection site for 15 to 30 seconds with an alcohol swab. Observe the site. If there is any sign of bruising, reapply pressure for several minutes. If bleeding occurs, maintain this pressure on injections sites until the bleeding stops. Massage the organ to help the medicine spread throughout.
- If there is any solution left in the syringe DO NOT KEEP for subsequent use.
- The syringe is for single use only. Do not reuse or share needles or syringes.
Dispose of all materials safely. Dispose needles in a sharps container or a specific screw-capped container.
All medicine treatment approaches can have side effects. Sometimes they are serious, most of the time they are not. You may need to seek medical treatment if you experience certain side effects. Ask your doctor or pharmacist to answer any questions you may have. Do not be alarmed by the list of possible side effects. You may not experience any of them.
Treatment with Trimix can result in the following side effects: priapism, penile pain, fibrous lumps, bruising at the injection site, dizziness and low blood pressure. Priapism is a prolonged erection lasting more than four hours. The reported incidence of priapism with these therapies varies between as little as 0.5% and up to 5% of patients. Excessive growth of fibrous tissue of the penis can occur if priapism is not treated.
Pain in the penis is one of the most common complaints with injectable erectile dysfunction treatment, being reported in as many as 80% of men. The pain is usually tolerable. Contact your prescriber if the pain is too great as this product may not be appropriate for you.
Fibrous lumps can occur as a result of injectable erectile dysfunction therapies or can be present as a result of radiation therapy or surgery. These lumps can sometimes resolve despite continued use. The occurrence of these lumps does not necessarily indicate a need to cease treatment.
Bruising can occur at injections sites. Bruising can be minimized with the use of a fine needle and should be minimal with proper injections technique.
Overdose and Treatment
An overdose of Trimix injections can lead to priapism.
Priapism is a painful prolonged penile erection in the absence of sexual stimulation. Your prescriber may give you a test dose in the clinic to determine an effective dose and screen for priapism.
The treatment of priapism is 120mg of pseudoephedrine taken orally. Symptoms should subside within four hours. If this fails to resolve the problem you should seek immediate medical attention.
If you are using Trimix injections for the first time, or an increased strength for the first time, you should make sure that you have access to pseudoephedrine which may be used in the event of the medication causing priapism.
Please note that the maximum dose of pseudoephedrine is 240mg in 24 hours (4x 60mg tablets).
In this video, we see the proper way to apply the TriMix Gel For ED: